Appendix
Appendix
Section titled “Appendix”End User Technical Requirements
Section titled “End User Technical Requirements”KerusCloud is a browser-based application, all memory and CPU intensive processing is completed in a scalable cloud service. Basic user requirements are:
• Supported browser, from the list below
• A stable internet connection
Recommended Web Browsers and Versions
Section titled “Recommended Web Browsers and Versions”KerusCloud has been developed to web standards. Recommended browsers, for KerusCloud, are the latest versions of standard compatible browsers:
• Google Chrome
• Mozilla Firefox
• Microsoft Edge
KerusCloud may work with other browsers, based on the same rendering frameworks as Chrome and/or Firefox, but this is not tested.
Internet Connection Recommendation
Section titled “Internet Connection Recommendation”It is recommended that to use KerusCloud there is a reliable internet connection, to the desktop, of minimum 1.5 MBps with a latency of no more than 50 ms.
Screen Resolution
Section titled “Screen Resolution”KerusCloud is designed for desktop/laptop use and as such is viewed best on higher resolution monitors, with a suggested minimum resolution of 1440 x 900 (or higher).
SAML Federated Single Sign-On
Section titled “SAML Federated Single Sign-On”By default, users can login to the KerusCloud application by entering valid username/password credentials on the Login screen. Users may also gain access to KerusCloud via Federated Single Sign-On (SSO). Federated SSO is a service that allows users to log into multiple applications & websites across different domains using a single set of login credentials.
Federated SSO makes uses of SAML 2.0 (Security Assertion Markup Language), an open and standardised method for passing authentication and authorisation information between an identity provider (your organisation) and a service provider (KerusCloud).
If you are interested in enabling Federated SSO with KerusCloud for your organisation, please contact KerusCloud Support, as we (Exploristics) would require some details from your IT administrator\department to set up.
Glossary of Terms
Section titled “Glossary of Terms”KerusCloud Task
Section titled “KerusCloud Task”KerusCloud tasks are R functions that are executed in the cloud environment, they consume the parameters gathered as variables and other data from the KerusCloud front end for the various stages of the KerusCloud application when the Go buttons are pressed.
• Virtual Population will result in a simulated population output file
• Study Design and Analysis will result in an analysis output file
• Decision Criteria will result in a decision criteria output file
Output Files
Section titled “Output Files”Data sets used as the input for the next step of the KerusCloud process.
Virtual Population feeds Study Design and Analysis
Study Design and Analysis feeds Decision Criteria
Decision Criteria feeds Visualisations
Timepoint
Section titled “Timepoint”A timepoint is a time value at which the data was obtained from the perspective of the patient. If a project has a recruitment variable, then not all patients will be recruited at the start of the trial. In this context the study time and timepoint of variables will differ.
Site Cap
Section titled “Site Cap”A Site Cap is an upper limit on the maximum number of patients (defined as a percent of total patient numbers for that sample size) that can come from an individual site.
Sensitivity
Section titled “Sensitivity”Measures the proportion of actual positives that are correctly identified as such e.g. suppose there is a diagnostic test for a disease then the sensitivity is the percentage of people who have the disease and who have a positive test result.
Specificity
Section titled “Specificity”Measures the proportion of actual negatives that are correctly identified as such e.g. suppose there is a diagnostic test for a disease then the specificity is the percentage of people who do not have the disease and who have a negative test result.
Significance
Section titled “Significance”The significant figures of a number are digits that carry meaning contributing to its measurement resolution. e.g. if 3 significant figures is requested then a value of 37592 would get rounded to 37600 . A value of 1.3007 would get rounded to 1.30 and a value of 0.0011 would get rounded to 0.001.
Pearson R
Section titled “Pearson R”A measure of the linear correlation between two variables X and Y.
Spearman Rho
Section titled “Spearman Rho”The Spearman correlation between two variables is equal to the Pearson correlation between the rank values of those two variables; while Pearson’s correlation assesses linear relationships, Spearman’s correlation assesses monotonic relationships (whether linear or not).
Kendall Tau
Section titled “Kendall Tau”A statistic used to measure the ordinal association between two measured quantities.
Right-censored
Section titled “Right-censored”A Time-to-Event variable is right-censored when the event has not occurred for an observation by the end of the study period or when the observation is lost to follow-up before the event occurs. In KerusCloud, this is defined by specifying an Event and Censor distribution as part of a Time-to-Event variable.